A di-electrophoretic simulation procedure of iron-oxide micro-particle drug attachment system for leukemia treatment using COMSOL software: a potential treatment reference for LMICs

This study presents a computational modeling approach using COMSOL Multiphysics software to develop a continuous flow microfluidic device for delivering anti-leukemia drugs to early-stage leukemia cells. The research utilizes dielectrophoresis (DEP) to enable micro-particle drug attachment to leukemia cells through hydrodynamic focusing from dielectrophoretic force. The model produces low voltage applications from numerically calculated electrical field and flow speed simulations, offering an economical and resourceful treatment approach particularly suitable for Low and Middle Income Countries (LMICs). The dielectrophoretic low voltage application model can serve as a computational treatment reference for early-stage leukemia cells with an approximate size of 5 μm.